Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy
نویسندگان
چکیده
منابع مشابه
Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy
BACKGROUND Kidney injury molecule-1 (KIM-1) is a biomarker useful for detecting early tubular damage and has been recently reported as a useful marker for evaluating kidney injury in IgA nephropathy (IgAN). We therefore investigated whether treatment decreases urinary KIM-1 excretion in IgAN. METHODS We prospectively enrolled 37 patients with biopsy-proven IgAN. Urinary KIM-1 was assessed bef...
متن کاملUrinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity.
BACKGROUND The pathological characteristics of IgA nephropathy (IgAN) are highly variable. Urinary kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubule injury. The aim of the study is to investigate the value of KIM-1 as a biomarker for assessing the renal injury in IgAN. METHODS The levels of urinary KIM-1 in 202 patients with IgAN, 46 patients with other renal disea...
متن کاملKidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation.
Tubulointerstitial injury plays an important role in the development and progression of chronic kidney disease (CKD). Kidney injury molecule (KIM)-1 is induced in damaged proximal tubules in both acute renal injury and CKD. However, the dynamics of KIM-1 in CKD and effects of KIM-1 expression on disease progression are unknown. Here, we aimed to determine the associations between tubular KIM-1 ...
متن کاملEvaluation of the urinary kidney injury molecule-1 levels in patients with diabetic nephropathy.
PURPOSE Kidney Injury Molecule-1 is a protein that increases in urine following tubular damage. Kidney Injury Molecule-1 levels were correlated with the level of chronic kidney disease secondary to diabetic nephropathy in patients with type 2 Diabetes Mellitus. METHODS Clinical and laboratory findings of 142 patients with diabetic nephropathy and 34 control subjects were analysed. Creatinine ...
متن کاملTubular kidney injury molecule-1 in protein-overload nephropathy.
Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and detectable in urine. We studied Kim-1 in a nontoxic, nonischemic, model of tubulointerstitial damage ...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2013
ISSN: 1471-2369
DOI: 10.1186/1471-2369-14-139